Endocrine Abstracts

Oncogenic activation and anticancer therapies are known to evoke – especially if apoptotic cell death is no longer available – cellular senescence as another stress-responsive safeguard and ultimate cell-cycle exit program in (pre-)malignant cells. Hence, oncogene-induced senescence (OIS) and therapy-induced senescence (TIS) are considered to operate as important anti-tumor principles. However, we previously reported (Dörr-JR et al., Nature, 2013) that ...